Intracanal medications play a vital role in reducing microbial load and controlling inflammation during endodontic treatment. This presentation explores the immunologic mechanisms activated by these medications, such as calcium hydroxide and modified antibiotics, and how they correlate with clinical outcomes. By examining the host’s immune response, including cytokine modulation and tissue healing, we will assess how effective intracanal medicaments enhance endodontic success. Clinical cases and recent research will highlight practical implications, guiding evidence-based decisions for optimal patient care.