This lecture will provide an in-depth examination of root canal irrigation, emphasizing its vital role in successful endodontic treatment. We will explore various irrigation solutions, their antimicrobial properties, and the importance of activation techniques for effective cleaning. Special attention will be given to often-overlooked aspects of irrigation practices, including the latest advancements in technology and methodology. Attendees will leave with practical strategies to enhance their irrigation protocols and improve patient outcomes in endodontics.