Despite the solid principles of ‘Biomimetic Restorative Dentistry’, there remain numerous challenges and questions regarding scientific validity of many of its protocols, which are often marketed as superior options to current adhesive dentistry, despite lacking strong scientific evidence to substantiate such claims. Therefore, this lecture aims to explore the origins of BRD and critically appraise its protocols in several clinical scenarios following evidence-based practice principles. Some biases will be highlighted that had led dentists to adopt BRD without sufficient scientific support, considering it as the new standard of care.